Peptide Therapy

Home / Peptide Therapy

What is Peptide Therapy?

A peptide is a short chain of amino acids that are linked together and can be thought of as a small protein. To date, over 7,000 naturally-occurring peptides have been identified in our bodies. These small proteins act as signaling molecules. They bind to receptors on the cell surface and tell other cells and molecules what to do.

Peptide therapy, or the use of specific peptides in treatment, has gained great popularity in recent years. This is due largely to the fact that these peptides are highly specific (i.e., only do what you want them to do) while also being well-tolerated and safe. There are over 70 US FDA-approved peptide medications, 140 peptide drugs being evaluated in clinical trials, and 500 in pre-clinical development.

Most of these peptide drugs are administered intradermally, but can also come in the form of transdermal creams, nasal sprays, and oral tablets.

What Conditions Does Peptide Therapy Address?

Because these peptides are so numerous and variable in structure, their effects are likewise varied and wide-ranging. One class of these peptides are known as growth hormone secretagogues and cause the secretion of one’s own, natural hGH in the body. These peptides have been shown to be very useful in the treatment of age-related conditions, osteoporosis, obesity, and various chronic inflammatory diseases, lower libido, and have several advantages over traditional hGH administration.

Another type of peptide drug is composed of part of the hGH molecule that is responsible for fat cell death and has been shown to be very effective as an anti-obesity drug. In addition to decreasing inflammation, these drugs lead to increased lean muscle mass and decreased body fat.  Other peptides work  to increase libido naturally and are effective for  erectile dysfunction (ED)

Below is a list of the more common peptides that we use at the Renaissance Health Centre.

 CJC 1295

This particular peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.

GHRP 2

Growth hormone releasing peptide (GHRP) 2 is a type of peptide therapeutic that mimics the effects of ghrelin, the “hunger hormone”. Ghrelin is a hormone that helps regulate appetite as well as energy distribution and rate of use or metabolism. In the 1980’s, ghrelin was discovered to be the body’s natural ligand (or binding molecule) of the GHRP receptor in the anterior pituitary. This was a significant discovery, as it highlighted the role of ghrelin in hGH secretion and growth regulation. Modern biotechnology has used this knowledge to develop peptides that can be administered to mimic ghrelin’s hGH stimulation but in a more targeted fashion. GHRP 2 is one such peptide, stimulating hGH secretion by 7-15 times, increasing appetite and meal initiation, while also decreasing fat mass and cholesterol. GHRP 2 is ideal for patients who are hypercatabolic, due to critical illness, cancer, AIDS, etc. It should be noted that GHRP 2 can also increase levels of prolactin, aldosterone, and cortisol.

Bremelanotide PT 141

Bremelanotide PT 141 was developed from Melanotan II, targeting its aphrodisiac effects. This peptide has been shown to have a substantial effect on libido, generating sexual arousal in both men and women within minutes of administration. It has been shown to be effective in treating erectile dysfunction, even in men who have not responded to other ED treatments, such as Viagara. This peptide is also able to cross the blood-brain-barrier, bypassing the vascular system and acting at the level of the central nervous system. This property gives Bremelanotide an advantage over traditional ED drugs, which can decrease blood pressure to dangerous levels. This peptide can be administered as a nasal spray, making its use convenient and discreet.

MGF

MGF stands for mechano growth factor—a peptide derived from insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. MGF has the ability to encourage repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This peptide is ideal of anyone suffering from muscle loss, either due to old age or a particular condition (i.e., HIV, cancer, etc.)

Cerebrolysin

Cerebrolysin—also known as FPE 1070—is a synthetic nootropic drug. Nootropic drugs are substances that enhance cognitive functions such as memory, creativity, and motivation in otherwise healthy individuals. This peptide is extremely small, allowing it to penetrate the blood-brain barrier and act directly on the neurons of the central nervous system. Cerebrolysin has been found to improve the metabolic activity of brain tissue, shield neurons from harmful substances, and stimulate the peripheral and central nervous systems. In addition to its utility as a nootropic substance, the drug has potential as part of a treatment plan addressing Alzheimer’s disease, stroke, and moderate to severe head injury.

Ta1

This peptide supports and balances the immune system.  As most chronic diseases are directly related to immune dysfunction

Ta1 has been shown to help with a wide array of illnesses. Below are listed just a few health conditions that benefit from Ta1:

  • Depression
  • Metabolic Syndrome
  • Weigh management issues
  • Insulin resistance and type 2 diabetes
  • Anti-Aging effects – increased oxidative stress
  • Chronic fatigue syndrome/fibromyalgia
  • Autoimmune conditions
  • Cancer
  • Chronic
  • Environmental toxins
  • Chronic infections, including Lyme, viruses, candida and many parasites
  • Glutathione depletion consistently results in TH1-TH2 shift
  • Dysbiosis
  • Food allergies or sensitivities

In-house
Compounding
Pharmacy

Our pharmacist Danny Gelber has taken great care in formulating bio-identical hormones sourced from plants. Because we compound on site we can provide fast convenient customized Hormone replacement therapy. In addition, we offer anti-wrinkle cream, topical analgesic cream for pain, hair growth formula, and low dose naltrexone.

holisitc pharmacist makes compound

Some of the
Health Issues
that we treat


  • Chronic fatigue
  • Insomnia
  • Anxiety
  • Autism
  • Depression
  • Anti-aging
  • Cancers
  • Allergies
  • Arthritis
  • Back and joint pain
  • Headaches/migraines
  • GERD
  • Fibromyalgia
  • Menopause
  • Hypercholesterolemia
  • Eczema
  • more

Depression in Children

About three weeks ago I was watching NBC nightly news when a segment came on talking about depression in children. The American Academy of Child and Adolescent Psychiatry describes depression in children and teens as follows: Not only adults become depressed. Children...

read more

The Pain that Wouldn’t Go Away, Leaves

Neuralgia, trigeminal  (nu-ral’ji-a) [Gr. neuron, sinew, + algos, pain]  is a severe sharp pain along the course of the fifth cranial nerve.   Attacks are often precipitated by initiation of pain by obvious stimuli of certain hypersensitive areas of face lips, or...

read more