Fenbendazole (FBZ), is a well-known anti-helminthic drug. It is commonly prescribed to treat a range of parasitical worm infections, including threadworm tapeworms, roundworms, and other nematode infections in humans and domestic animals. FBZ has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies with a number of different cancer types.
Pre-clinical studies of FBZ has been shown to have apoptotic effects on a wide range of solid tumors including lung cancers including NSCLC, breast(ER+ invasive ductal carcinoma), ovarian, colorectal carcinomas, acute myeloid leukemia, lymphoma, adrenal cortical, Glioblastoma multiforme, melanoma, and osteosarcoma while not affecting healthy cells. One study on mice with approximately 300 metastatic colonies treated with FBZ showed a mean colony count reduction of 80%. Another study found that FBZ significantly extended the survival of mice with glioblastoma multiforme up to 63%.
The fight against cancer has been one of isolation and selectively poisoning the cells, When cancer cells have integrated themselves in vital tissues, this becomes a major problem. Often, surgical attacks on cancerous tissue seem to stimulate their growth, even more, resulting in a temporary relapse with re-growth. Likewise, chemotherapy and radiation are not selective enough to protect healthy cells and their method of death is toxic.
Fenbendazole is different. FBZ is known to interfere and inhibit the assemble and disassemble of the spindles, thus preventing the ability of the cells to divide. The cell eventually dies of old age or apoptosis. FBZ is highly selective and somehow targets only cancerous cells (as well as a host of intestinal parasites). Other studies that FBZ kills cancer cells through its effect on the mitochondrial function (energy-producing organelles in cells) and angiogenesis (the ability to create blood vessels that supply nutrients to the cancerous cells). FBZ also turns on the P53 gene. The P53 gene is found in all cells. This gene is used to prevent cells from turning cancerous. When a cell mutates to the point of cancer, the P53 gene is turned off. Fenbendazole turns this gene back on, basically killing the cancer cell from the inside out. It has also been shown to inhibit invasion, migration and metastases formation.
We are currently recommending this alternative therapy for our cancer patients as it has very few adverse effects. I am anxious to see what effects this has on our patients.
Terry Pfau DO, HMD